Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000003" target="_blank" >RIV/00027162:_____/24:N0000003 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1470204523006228?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1470204523006228?via%3Dihub</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid
Original language description
In November, 2023, a Working Group of 30 scientists from 11 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of two agents: perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), including their corresponding isomers and salts. PFOA was classified as “carcinogenic to humans” (Group 1) based on “sufficient” evidence for cancer in experimental animals and “strong” mechanistic evidence in exposed humans. The evidence for cancer in experimental animals was “sufficient” because an increased incidence of an appropriate combination of benign and malignant neoplasms was observed in both sexes of a single species in a Good Laboratory Practice (GLP) study. PFOS was classified as “possibly carcinogenic to humans” (Group 2B) based on “strong” mechanistic evidence. The evidence for cancer in experimental animals was “limited” for PFOS, and the evidence regarding cancer in humans was “inadequate”. These assessments will be published in Volume 135 of the IARC Monographs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Lancet Oncology
ISSN
1470-2045
e-ISSN
1474-5488
Volume of the periodical
25
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
16-17
UT code for WoS article
001154583000001
EID of the result in the Scopus database
2-s2.0-85181778127