The Superior Effect of Radiofrequency With Targeted Ultrasound for Facial Rejuvenation by Inducing Hyaluronic Acid Synthesis: A Pilot Preclinical Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000022" target="_blank" >RIV/00027162:_____/24:N0000022 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/asjopenforum/article/doi/10.1093/asjof/ojae005/7593491" target="_blank" >https://academic.oup.com/asjopenforum/article/doi/10.1093/asjof/ojae005/7593491</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/asjof/ojae005" target="_blank" >10.1093/asjof/ojae005</a>
Alternative languages
Result language
angličtina
Original language name
The Superior Effect of Radiofrequency With Targeted Ultrasound for Facial Rejuvenation by Inducing Hyaluronic Acid Synthesis: A Pilot Preclinical Study
Original language description
The level of dermal hyaluronic acid can be depleted by 75% at age 70. HA, a glycosaminoglycan, provides dermal hydration, volume, and thickness, making it a major component of the extracellular matrix. Restoration of dermal and epidermal hyaluronic acid can be achieved by combining radiofrequency energy and targeted ultrasound. The monopolar radiofrequency (RF) generates heat, with the targeted ultrasound (TUS) stimulating hyaluronic acid production. The heat induces a regenerative response in the skin, increasing the fibroblast activity and producing various extracellular matrix compounds, including hyaluronic acid (HA). Objective: To investigate the effect of the simultaneous application of RF+TUS or RF+US on the stimulation of hyaluronic acid production. Materials and Methods: Twelve animals underwent four treatments. Six were treated with transcutaneous RF+TUS and six with the combination RF+US. The opposite untreated side served as a control. Punch biopsies of the skin were taken at baseline, immediately post-treatment, 1 month, and 2 months post-treatment. Tissue was evaluated with RT-qPCR, MALDI-TOF, and confocal microscopy. Results: The RT-qPCR focused on assessing the production of has1 and has2, enzymes responsible for HA synthesis. RT-qPCR results of the RF+TUS group revealed a +98% and +45% increase in HAS1 and HAS2 production after the treatments, respectively. The MALDI-TOF revealed a +224% increase in measured hyaluronic acid 2 months after the treatments. The changes were also visible in the confocal microscopy. The control group showed no significant (p-value > 0.05) results in either of the evaluation methods. Conclusion: Concurrent application of radiofrequency and targeted ultrasound significantly enhances the natural regenerative processes in skin tissue.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30206 - Otorhinolaryngology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aesthetic Surgery Journal
ISSN
1090-820X
e-ISSN
1527-330X
Volume of the periodical
6
Issue of the periodical within the volume
2024
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
001163645700001
EID of the result in the Scopus database
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