Ovine and Caprine Strains of Corynebacterium pseudotuberculosis on Czech Farms—A Comparative Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000037" target="_blank" >RIV/00027162:_____/24:N0000037 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2076-2607/12/5/875" target="_blank" >https://www.mdpi.com/2076-2607/12/5/875</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/microorganisms12050875" target="_blank" >10.3390/microorganisms12050875</a>

Result language
angličtina
Original language name
Ovine and Caprine Strains of Corynebacterium pseudotuberculosis on Czech Farms—A Comparative Study
Original language description
In this study, 33 strains of C. pseudotuberculosis were isolated from sheep and goats suffering from CLA on nine farms in the Czech Republic. All these strains were tested for their antibiotic susceptibility, ability to form a biofilm and resistance to the effects of commonly used disinfectant agents. To better understand the virulence of C. pseudotuberculosis, the genomes of strains were sequenced and comparative genomic analysis was performed with another 123 genomes of the same species, including ovis and equi biovars, downloaded from the NCBI. The genetic determinants for virulence factors responsible for adherence, virulence factors specialized for iron uptake and exotoxin phospholipase D were revealed in every analyzed genome. Carbohy-drate-Active Enzymes were compared revealing the presence of genetic determinants encoding exo-α-sialidase (GH33) and CP40 protein in most of the analyzed genomes. Thirty-three Czech strains of C. pseudotuberculosis were identified as the biovar ovis on the basis of comparative genome analysis. All the compared genomes of the biovar ovis strains were highly similar regardless of their country of origin or host, reflecting their clonal behavior.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
<a href="/en/project/QK1910082" target="_blank" >QK1910082: Addressing the problem of the occurrence of bacterial, protozoan and viral zoonotic agents in small ruminant breeds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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