Might great variability of porcine rotavirus a hamper the vaccine efficacy in pigs?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000071" target="_blank" >RIV/00027162:_____/24:N0000071 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Might great variability of porcine rotavirus a hamper the vaccine efficacy in pigs?

Original language description

Rotaviruses (RVs) belong to the Reoviridae family and are a major cause of acute viral gastroenteritis in young animals, including piglets. During our study in 2016-2019, 167 samples of domestic pigs faeces were screened for the presence of RVA and 44.9% were tested positive (n=75). The most common porcine G-genotypes were G9 (36% of all RVA-positive samples), G4 (26%), G5 (17%), and G11 (12%) in combination with different P-types (mostly with P[6] and P[13]). Most commercial farms in the Czech Republic use rotavirus vaccines intended for the active immunization of pregnant sows and gilts for the induction of colostral and lactogenic immunity in newborn piglets. However, those vaccines include only RVA strain OSU which is of G5P[7] genotype. The ongoing surveillance of porcine RVA genotypes (2020-2023) showed another increase in non-G5 genotypes representation (50% of G9, 28% of G4, and 7% of G9). Only 5% of successfully genotyped samples were of G5 genotype. Similar changes in the human RVA genotypes proportions were demonstrated in several large-scale molecular epidemiological studies after introduction of the vaccination in different countries suggesting the possibility of RVA escape from vaccine-induced immune pressure. Therefore, continuing surveillance studies of porcine rotavirus genotypes are needed to monitor the dynamics of RVA and to be able to responsibly evaluate the effectiveness of RVA vaccines used in swine production.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

<a href="/en/project/TN02000017" target="_blank" >TN02000017: National Centre for Biotechnology in Veterinary Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů