Role of gemini surfactants with biodegradable spacer as efficient capping agents of silver nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000087" target="_blank" >RIV/00027162:_____/24:N0000087 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1773224724008311" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224724008311</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2024.106162" target="_blank" >10.1016/j.jddst.2024.106162</a>

Result language

angličtina

Original language name

Role of gemini surfactants with biodegradable spacer as efficient capping agents of silver nanoparticles

Original language description

Since the last decade, silver nanoparticles (AgNPs) continue to attract interest of both academia and industry due to their peculiar physical, chemical, and optical properties. In the field of pharmaceutical applications, they are efficient carriers in the processes of controlled drug release, improve the drug's bioavailability, act as efficient antimicrobial agents and provide other biological functions conveyed at the nanometric scale. The known issue hampering further development of applications of AgNPs is their instability in aqueous environment. The present study utilizes two series of cationic bisammonium gemini surfactants with two dodecyl chains and a biodegradable spacer containing two amide or ester groups for the stabilization of AgNPs. The presence of nanosilver in the dispersions was confirmed by UV–VIS plasmon resonance spectra. Stability of AgNPs was characterized by zeta potential measurements proving that amide and ester gemini surfactant series are able to effectively stabilize AgNPs. The particles size analysis utilizing dynamic light scattering and scanning electron microscopy showed that AgNPs stabilized with flexible ester-based gemini surfactants have their size smaller than those capped with amide-containing gemini surfactants. Antimicrobial and anti-inflammatory activity determination as well as cytotoxicity experiments with gemini surfactant stabilized AgNPs showed a complex dependence of biological activity of AgNPs on the molecular structure of stabilizing agents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

e-ISSN

2588-8943

Volume of the periodical

101

Issue of the periodical within the volume

2024

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

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UT code for WoS article

001315633200001

EID of the result in the Scopus database

2-s2.0-85203464839