Porcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosa
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000102" target="_blank" >RIV/00027162:_____/24:N0000102 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/24:PU152417 RIV/00216224:14110/24:00136816 RIV/65269705:_____/24:00080251 RIV/00159816:_____/24:00080251
Result on the web
<a href="https://vetmed.agriculturejournals.cz/artkey/vet-202406-0004_porcine-model-of-a-complicated-skin-and-soft-tissue-infection-caused-by-pseudomonas-aeruginosa.php" target="_blank" >https://vetmed.agriculturejournals.cz/artkey/vet-202406-0004_porcine-model-of-a-complicated-skin-and-soft-tissue-infection-caused-by-pseudomonas-aeruginosa.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.17221/25/2024-VETMED" target="_blank" >10.17221/25/2024-VETMED</a>
Alternative languages
Result language
angličtina
Original language name
Porcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosa
Original language description
Pseudomonas aeruginosa poses a significant threat to both immunocompetent and immunocompromised individuals, often resulting in life-threatening infections. With increasing antimicrobial resistance, novel therapeutic strategies are urgently needed. Although animal models are crucial for preclinical studies, limited data are available for porcine models, more specifically for P. aeruginosa complicated skin and soft tissue infections (cSSTIs). This study presents a novel porcine model inducing and sustaining cSSTI for 14 days. Six pigs (120 wounds) were used for the development of infections, and within this group, two pigs (40 wounds) were used to evaluate the progression of the cSSTI infection. The model demonstrated bacterial loads of more than 107 CFU/gram of tissue or higher. The cSSTI fully developed within three days and remained well above these levels until day 14 post-infection. Due to the immunocompetence of this model, all the immunological processes associated with the response to the presence of infection and the wound healing process are preserved.
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NU22-05-00475" target="_blank" >NU22-05-00475: Treatment of Infections Caused by Multidrug-Resistant Bacterial Strains by Novel Antibacterial Preparations Based on Cathelicidin Antimicrobial Peptides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Veterinární medicína
ISSN
0375-8427
e-ISSN
1805-9392
Volume of the periodical
69
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
191-197
UT code for WoS article
001259631600002
EID of the result in the Scopus database
2-s2.0-85197085166