Spontaneous exophytic tumour in Nothobranchius furzeri, an aging research model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000123" target="_blank" >RIV/00027162:_____/24:N0000123 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/24:00137287

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jfd.14021" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jfd.14021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jfd.14021" target="_blank" >10.1111/jfd.14021</a>

Result language

angličtina

Original language name

Spontaneous exophytic tumour in Nothobranchius furzeri, an aging research model

Original language description

Understanding the nature and diversity of spontaneous neoplasias in a model organism is of peculiar interest to toxicologists and biogerontologists who assess their prevalence in relation to experimental treatments (Wolf et al., 2015). In fishes, exophytic neoplasias are frequently found due to their conspicuous appearance on the body (Roberts, 2012; Vergneau-Grosset et al., 2017). Papillomas are the most common exophytic epithelial fish tumours with a predominant proliferation of epidermal cells with no to little presence of connective tissue (Roberts, 2012). Other exophytic tumours are derived from connective tissue as in fibromas, myxomas and fibromyxomas. Myxomas are soft tumours formed by immature connective tissue with extensive myxoid stroma. In contrast, a fibroma is a firm tumour derived from fibrous connective tissue (Roberts, 2012). Fibromyxomas share some traits of myxoma and fibroma and commonly consist of proliferating connective tissue characterized by neoplastic growth of stellate and spindled cells within the loose, collagenous and myxoid matrix with a low number of mitotic figures (Manera et al., 1997; Pittman & Montgomery, 2015; Vergneau-Grosset et al., 2017). They are typically well-vascularized and are connected to the subcutaneous musculature (Mocellin, 2021; Song et al., 2016). The prevalence of neoplasia in teleost fishes, including laboratory model organisms, is disproportionally biased due to frequent confusion with pathogen-induced lesions (Dyková et al., 2021; Harshbarger, 1984). Therefore, it is always important to test for the presence of known pathogens in the examined animal with neoplasia. Here, we report a case of spontaneous fibromyxoma, in senescent laboratory-kept turquoise killifish Nothobranchius furzeri. Turquoise killifish are a rapidly aging species with a life expectancy of several months in the wild because they inhabit seasonally inundated pools in Southeast African savanna (Reichard & Polačik, 2018). In captivity, they live approximately 1 year; therefore, they have become a popular model organism in biogerontology and toxicology (Cellerino et al., 2016; Thoré et al., 2021).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Fish Diseases

ISSN

0140-7775

e-ISSN

1365-2761

Volume of the periodical

47

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

"e14021"

UT code for WoS article

001313094700001

EID of the result in the Scopus database

2-s2.0-85204085814