MicroRNA Profiling of Bone Marrow Plasma Extracellular Vesicles in Multiple Myeloma, Extramedullary Disease, and Plasma Cell Leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000008" target="_blank" >RIV/00027162:_____/25:N0000008 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00140487 RIV/65269705:_____/25:00081135
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/hon.70036" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/hon.70036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hon.70036" target="_blank" >10.1002/hon.70036</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNA Profiling of Bone Marrow Plasma Extracellular Vesicles in Multiple Myeloma, Extramedullary Disease, and Plasma Cell Leukemia
Original language description
Multiple myeloma is a plasma cell malignancy characterized by an abnormal increase in monoclonal immunoglobulins. Despitesignificant advances in treatment, some patients progress to more aggressive forms of multiple myeloma, including extra-medullary disease or plasma cell leukemia. Although the exact molecular mechanisms are not known, several studies haveconfirmed the involvement of small extracellular vesicle‐enriched microRNAs in multiple myeloma progression. Therefore, weperformed expression profiling of these molecules in bone marrow plasma of multiple myeloma, extramedullary disease, andplasma cell leukemia patients using small RNA sequencing to identify novel molecules involved in disease pathogenesis. Intotal, 42 microRNAs were significantly dysregulated among analyzed subgroups. Independent validation by RT‐qPCRconfirmed elevated levels of miR‐140‐3p, miR‐584‐5p, miR‐191‐5p, and miR‐143‐3p in multiple myeloma patients comparedto extramedullary disease and plasma cell leukemia patients. Subsequent statistical analysis revealed significant correlationsbetween patient clinical characteristics or flow cytometry parameters and microRNA expression. These results indicate thatdysregulation of microRNAs could contribute to multiple myeloma progression.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hematological Oncology
ISSN
0278-0232
e-ISSN
1099-1069
Volume of the periodical
43
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
47
Pages from-to
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UT code for WoS article
001397146000001
EID of the result in the Scopus database
2-s2.0-85214787722