Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000048" target="_blank" >RIV/00027162:_____/25:N0000048 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065?af=R" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065?af=R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jfb.16065" target="_blank" >10.1111/jfb.16065</a>

Result language
angličtina
Original language name
Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)
Original language description
Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
40103 - Fishery

Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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