Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000075" target="_blank" >RIV/00027162:_____/25:N0000075 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/25:73633966
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/open.202500026" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/open.202500026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/open.202500026" target="_blank" >10.1002/open.202500026</a>

Result language
angličtina
Original language name
Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)
Original language description
The long-known dinuclear complexes of the general formula [M(μ-X)(η5-Cp*)X]2 (1–4; M=Rh or Ir, X=Br or I; HCp*= pentamethylcyclopentadiene) represent important intermediates for the preparation of biologically (e. g., anticancer or antimicrobial) and catalytically active half-sandwich rhodium(III) and iridium(III) complexes. Here we report the optimized rapid microwave-assisted syntheses of the mentioned dinuclear synthons 1–4. With respect to their following synthetic utilization, we examined their antiproliferative activity in the representative human cancer cell lines, where they did not show any relevant cytotoxicity. However, the iridium complexes 3 and 4 exhibited considerable catalytic activity in a model transfer hydrogenation of acetophenone using propan-2-ol as the hydrogen source. The obtained comprehensive data sets can be useful in the evaluation of the ligand effects in complexes prepared from 1–4 and used in e. g. Bioinorganic and catalytic applications.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/NU22-08-00236" target="_blank" >NU22-08-00236: Pre-clinical study of non-platinum metalodrugs for lung cancer therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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