Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000079" target="_blank" >RIV/00027162:_____/25:N0000079 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12220/25:43910915 RIV/00216224:14160/25:00143964
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo02323h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo02323h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d5fo02323h" target="_blank" >10.1039/d5fo02323h</a>
Alternative languages
Result language
angličtina
Original language name
Onion thiolanes as multifunctional molecules: a story about recently discovered compounds from a well-known vegetable
Original language description
Onion (Allium cepa L.) contains various bioactive organosulfur compounds, including recently identified species with a 3,4-dimethylthiolane ring structure. In this study, the biological activities of 24 onion-derived thiolane samples were comprehensively evaluated, focusing on antioxidant, anti-inflammatory, antidiabetic, and antimicrobial potential. Tested thiolanes showed significant antioxidant activity by reducing intracellular reactive oxygen species (ROS) levels in THP1-Blue™ NF-κB cells; however, some tested derivatives exhibited mild pro-oxidant effects. In assays targeting metabolic regulation, several compounds showed partial activation of the peroxisome proliferator-activated receptor gamma (PPARγ) pathway, particularly allithiolane B isomers, achieving 22–26% of the maximal response induced by the known full agonist rosiglitazone, suggesting potential as PPARγ modulators. Anti-inflammatory assessments revealed minimal direct inhibition of NF-κB signaling, except for onionin A, which modestly attenuated NF-κB activity. Cytotoxic evaluation indicated safety at physiological concentrations (up to 10 μM), though some thiolanes significantly reduced cell viability at higher concentrations (50 μM), highlighting their potential for selective cytostatic applications. Antimicrobial screening indicated limited activity against bacteria and fungi at tested concentrations, except for moderate antifungal effectiveness against Candida albicans shown by allithiolane D and cepathiolactols F. Overall, these results emphasise that onion thiolanes are multifunctional molecules capable of modulating oxidative stress, metabolic regulation and inflammation, supporting their potential use in nutraceutical strategies aimed at chronic disease prevention and management.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food & Function
ISSN
2042-6496
e-ISSN
2042-650X
Volume of the periodical
16
Issue of the periodical within the volume
18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
7094-7103
UT code for WoS article
001560015600001
EID of the result in the Scopus database
2-s2.0-105016096872