Anticoronavirus Activity of Uridine Glycoconjugates Containing a 1,2,3-Triazole Moiety
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000089" target="_blank" >RIV/00027162:_____/25:N0000089 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/25:00143234
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c01602" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c01602</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jmedchem.5c01602" target="_blank" >10.1021/acs.jmedchem.5c01602</a>
Alternative languages
Result language
angličtina
Original language name
Anticoronavirus Activity of Uridine Glycoconjugates Containing a 1,2,3-Triazole Moiety
Original language description
Coronaviruses can spread rapidly to new host species and cause severe respiratory and enteric diseases in vertebrates, including humans. To date, seven coronaviruses have been identified in humans, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) being the most notorious due to its substantial social and economic impact. Although anti-SARS-CoV-2 vaccines are available, infections remain widespread, highlighting the ongoing need for antiviral treatments. Here, we report the synthesis and evaluation of the activity of uridine glycoconjugates, designed as glycosyltransferase donor-type inhibitors incorporating a 1,2,3-triazole moiety. These compounds were tested against two model coronaviruses: murine hepatitis virus strain A59 (MHV) and human coronavirus strain NL63 (HCoV-NL63). Four of the synthesized compounds demonstrated strong antiviral activity against both viruses, and their efficacy was further confirmed against SARS-CoV-2. Our results suggest that these compounds interfere with the coronavirus infectivity and replication process. Thus, these novel compounds may prove to be effective broad-spectrum antiviral inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Medicinal Chemistry
ISSN
0022-2623
e-ISSN
1520-4804
Volume of the periodical
68
Issue of the periodical within the volume
16
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
17859–17873
UT code for WoS article
001546624100001
EID of the result in the Scopus database
2-s2.0-105014388597