From Genes to Organs: A Multi-Level Neurotoxicity Assessment Following Dietary Exposure to Glyphosate and Its Metabolite Aminomethylphosphonic Acid in Common Carp (Cyprinus carpio)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000189" target="_blank" >RIV/00027162:_____/25:N0000189 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2076-3417/15/22/11877" target="_blank" >https://www.mdpi.com/2076-3417/15/22/11877</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app152211877" target="_blank" >10.3390/app152211877</a>

Result language

angličtina

Original language name

From Genes to Organs: A Multi-Level Neurotoxicity Assessment Following Dietary Exposure to Glyphosate and Its Metabolite Aminomethylphosphonic Acid in Common Carp (Cyprinus carpio)

Original language description

Herbicide glyphosate and its main metabolite, aminomethylphosphonic acid (AMPA), have raised concerns due to their potential neurotoxicity in non-target aquatic species. This study evaluated neurotoxic effects in common carp (Cyprinus carpio) following a 28-day dietary exposure to glyphosate (325.2 and 3310.0 μg/kg) and AMPA (335.2 and 3441.0 μg/kg) at two concentrations, including control and four treatment groups. Brain acetylcholinesterase activity was significantly (p < 0.05) reduced in all exposed groups, while muscle acetylcholinesterase activity remained unchanged. Brain dopamine was significantly (p < 0.05) decreased only in the highest AMPA group. Plasma butyrylcholinesterase activity increased significantly (p < 0.05) in the low-dose glyphosate group. The level of mRNA expression of ache was significantly (p < 0.05) downregulated in the brain across all treatments and upregulated in the gills only at the highest AMPA concentration. Histological analysis of the brain revealed vascular congestion in both glyphosate-exposed groups, indicating pathological changes. These results suggest that dietary exposure to glyphosate and AMPA can affect cholinergic and dopaminergic pathways in fish, with the brain being a particularly sensitive target tissue. Our findings contribute to understanding the potential neurotoxic risks posed by glyphosate-based compounds in aquatic environments.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40103 - Fishery

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Sciences

ISSN

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e-ISSN

2076-3417

Volume of the periodical

15

Issue of the periodical within the volume

22

Country of publishing house

CH - SWITZERLAND

Number of pages

17

Pages from-to

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UT code for WoS article

001625488000001

EID of the result in the Scopus database

2-s2.0-105022979140