Response to treatment in women with chronic myeloid leukemia during pregnancy and after delivery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F09%3A5814" target="_blank" >RIV/00064165:_____/09:5814 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/09:5814 RIV/00023736:_____/09:00008236
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Response to treatment in women with chronic myeloid leukemia during pregnancy and after delivery
Original language description
We report response to treatment of 5 pregnant women with CML during and after pregnancy. CML was diagnosed during pregnancy in 3 patients, while 2 patients became pregnant during CML. Interferon alpha with leukapheresis when needed was applied in the 2ndand 3rd trimester. We describe that all patients except one achieved complete hematological response during pregnancy. After delivery four patients achieved partial cytogenetic response on imatinib and two patients achieved major molecular response after crossover to dasatinib. We conclude that the pregnancy of our CML patients did not substantially negatively influence their further response to treatment, in comparison to other patients.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NR8758" target="_blank" >NR8758: Early markers of resistance to imatinib in chronic myeloid leukemia treatment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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