The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F10%3A6450" target="_blank" >RIV/00064165:_____/10:6450 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/10:6450
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
Original language description
This review summarizes the indispensable requirement of transcription factor PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein?protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9021" target="_blank" >NR9021: Mouse conditional model of chromatin remodeling factor Snf2h inactivation to study its role in hematopoiesis and leukemogenesis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
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UT code for WoS article
000279892900002
EID of the result in the Scopus database
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