High-risk human papillomavirus DNA in paraaortic lymph nodes in advanced stages of cervical carcinoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F11%3A10160" target="_blank" >RIV/00064165:_____/11:10160 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/11:10160
Result on the web
<a href="http://dx.doi.org/10.1016/j.jcv.2010.09.020" target="_blank" >http://dx.doi.org/10.1016/j.jcv.2010.09.020</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
High-risk human papillomavirus DNA in paraaortic lymph nodes in advanced stages of cervical carcinoma
Original language description
Background: Paraaortic lymph nodes represent the second level in the lymphatic spread of cervical cancer. Recent studies have confirmed the association of HPV DNA in pelvic lymph nodes in early-stage disease with metastatic involvement and a less favourable prognosis. Objective: The aim of our study was to detect 13 high-risk genotypes of HPV in paraaortic nodes harvested from patients with FIGO IB2-IIIB tumours and correlate findings with histopathology. Study design: The study involved patients with advanced cervical cancer who had undergone low paraaortic lymphadenectomy. The cytobrush technique was used for perioperative sample collection from the tumour and fresh lymphatic tissue. Patients with non-HPV related cancers were used as a control group.Results: The study involved 24 cervical cancer patients. High-risk HPV DNA was found in the primary tumour of all cases and in PALN in 16 (67%) cases. The most frequent genotype was HPV 16, both in the tumour and in the paraaortic lymph
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Project
<a href="/en/project/NS10037" target="_blank" >NS10037: Detection of subclinical metastasis in lymphatic nodes in early stages cervical cancers using detection of human papillomavirus DNA</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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