Comparative analysis of loss of heterozygosity and expression profi le in normal tissue, DCIS and invasive breast cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F11%3A10952" target="_blank" >RIV/00064165:_____/11:10952 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/11:10952

Result on the web

<a href="http://dx.doi.org/10.1007/s12094-011-0710-1" target="_blank" >http://dx.doi.org/10.1007/s12094-011-0710-1</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Comparative analysis of loss of heterozygosity and expression profi le in normal tissue, DCIS and invasive breast cancer

Original language description

Ductal carcinoma in situ (DCIS) is considered to be related to the development of invasive breast cancer. The aim of molecular biological research of preinvasive breast lesion characteristics and comparison with normal tissues and tissue of invasive tumours is to identify patients at high risk of developing invasive tumour on the basis of already established preinvasive lesions, and thus influence clinical decision-making. The aim of our study was to analyse several key molecules involved in different cellular pathways important for cancer development and progression in different types of breast tissue and to describe similarities and differences between premalignant and malignant lesions. Genetic material isolated from both the tumour and healthy tissue was examined by loss of heterozygosity (LOH) analysis and real-time PCR using collagen 2A as a house-keeping gene. We analysed 65 samples of healthy mammary gland, 25 DCIS and 42 invasive ductal breast cancer samples. We analysed the L

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

<a href="/en/project/NS10566" target="_blank" >NS10566: Molecular characteristics of borderline ovarian tumors in relation to their biological behavior</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical & translational oncology

ISSN

1699-048X

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

652-655

UT code for WoS article

000294561500007

EID of the result in the Scopus database

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