Jumping-like translocation-a rare chromosomal rearrangement in a patient with Burkitt lymphoma/leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F14%3A10284174" target="_blank" >RIV/00064165:_____/14:10284174 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/14:10284174 RIV/00023736:_____/14:00010819

Result on the web

<a href="http://dx.doi.org/10.1016/j.cancergen.2014.05.001" target="_blank" >http://dx.doi.org/10.1016/j.cancergen.2014.05.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cancergen.2014.05.001" target="_blank" >10.1016/j.cancergen.2014.05.001</a>

Result language

angličtina

Original language name

Jumping-like translocation-a rare chromosomal rearrangement in a patient with Burkitt lymphoma/leukemia

Original language description

Chromosomal translocations are acquired genetic rearrangements in human cancers. Jumping translocations are rare nonreciprocal rearrangements involving the same donor chromosome segment translocated to two or more recipient chromosomes. In this report, we describe a patient with Burkitt lymphoma/leukemia (BL) and a complex karyotype including a t(2;8)(p12;q24), copy-neutral loss of heterozygosity at 17p13.1-p13.3 and 19q13.1-q13.2, trisomy 20, and two uncommon chromosomal aberrations. The first uncommonaberration was a complex rearrangement of chromosome 15 (probably the consequence of chromothripsis) masked by an apparently balanced reciprocal translocation, t(11;15)(p11.2;q21). The second one was a special type of unbalanced "vice versa" jumping translocation, which involved the same acceptor chromosome arm (13q) and various donor chromosome segments. It is unclear whether both atypical rearrangements are the consequence of the TP53 alteration or whether assumed chromothripsis influ

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer genetics

ISSN

2210-7762

e-ISSN

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Volume of the periodical

207

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

221-225

UT code for WoS article

000340014200007

EID of the result in the Scopus database

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