Association of MTHFR genetic variants C677T and A1298C on predisposition to spontaneous abortion in Slavonic population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F15%3A10294780" target="_blank" >RIV/00064165:_____/15:10294780 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/15:10294780 RIV/00023001:_____/15:00059163

Result on the web

<a href="http://dx.doi.org/10.1016/j.cca.2014.11.018" target="_blank" >http://dx.doi.org/10.1016/j.cca.2014.11.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2014.11.018" target="_blank" >10.1016/j.cca.2014.11.018</a>

Result language

angličtina

Original language name

Association of MTHFR genetic variants C677T and A1298C on predisposition to spontaneous abortion in Slavonic population

Original language description

Aim: Up to 20% of pregnancies end in the first trimester by spontaneous abortion but the cause of a large proportion remains unexplained. The aim of this study was to investigate the role of two common variants (rs1801133, C677T and rs1801131, A1298C) within the MTHFR gene in the genetic determination of spontaneous abortions. Methods: DNA from 464 tissue samples of spontaneous abortions and population sample of adults (N = 2,486) were genotyped for both MTHFR polymorphisms of interest. Results: The frequencies of the MTHFR polymorphisms in tissues from spontaneous abortions did not differ from the population cohort. However, when combined, carriers of at least three rs1801133 and/or rs1801131 alleles were more common in the spontaneous abortions (61.4%) than in controls (55.4%) and this combination was associated with higher risk of abortion (OR 1.28; 95% CI 1.05-1.57; P = 0.017). In contrast, carriers of at least three minor alleles (T677 and C1298) of these polymorphisms were very rare in both groups (0.8% and 0.9% respectively). Conclusions: Our study suggests that distinct combinations of the MTHFR polymorphisms could be associated with higher risk of spontaneous abortions in Caucasians.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinica Chimica Acta

ISSN

0009-8981

e-ISSN

—

Volume of the periodical

440

Issue of the periodical within the volume

February

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

4

Pages from-to

104-107

UT code for WoS article

000349573900020

EID of the result in the Scopus database

2-s2.0-84911867743