Daclizumab high-yield process reduced the evolution of new gadolinium-enhancing lesions to T1 black holes in patients with relapsing-remitting multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10322308" target="_blank" >RIV/00064165:_____/16:10322308 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10322308

Result on the web

<a href="http://dx.doi.org/10.1111/ene.12922" target="_blank" >http://dx.doi.org/10.1111/ene.12922</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.12922" target="_blank" >10.1111/ene.12922</a>

Result language

angličtina

Original language name

Daclizumab high-yield process reduced the evolution of new gadolinium-enhancing lesions to T1 black holes in patients with relapsing-remitting multiple sclerosis

Original language description

Background and purposeIn the SELECT study, treatment with daclizumab high-yield process (DAC HYP) versus placebo reduced the frequency of gadolinium-enhancing (Gd+) lesions in patients with relapsing-remitting multiple sclerosis (RRMS). The objective of this post hoc analysis of SELECT was to evaluate the effect of DAC HYP on the evolution of new Gd+ lesions to T1 hypointense lesions (T1 black holes). MethodsSELECT was a randomized double-blind study of subcutaneous DAC HYP 150 or 300mg or placebo every 4weeks. Magnetic resonance imaging (MRI) scans were performed at baseline and weeks 24, 36 and 52 in all patients and monthly between weeks 4 and 20 in a subset of patients. MRI scans were evaluated for new Gd+ lesions that evolved to T1 black holes at week 52. Data for the DAC HYP groups were pooled for analysis. ResultsDaclizumab high-yield process reduced the number of new Gd+ lesions present at week 24 (P=0.005) or between weeks 4 and 20 (P=0.014) that evolved into T1 black holes at week 52 versus placebo. DAC HYP treatment also reduced the percentage of patients with Gd+ lesions evolving to T1 black holes versus placebo. ConclusionsTreatment with DAC HYP reduced the evolution of Gd+ lesions to T1 black holes versus placebo, suggesting that inflammatory lesions that evolved during DAC HYP treatment are less destructive than those evolving during placebo treatment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Neurology

ISSN

1351-5101

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

412-415

UT code for WoS article

000368797100039

EID of the result in the Scopus database

2-s2.0-84956827161