Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33 degrees C and 36 degrees C

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10325177" target="_blank" >RIV/00064165:_____/16:10325177 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10325177

Result on the web

<a href="http://dx.doi.org/10.1016/j.resuscitation.2015.10.013" target="_blank" >http://dx.doi.org/10.1016/j.resuscitation.2015.10.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.resuscitation.2015.10.013" target="_blank" >10.1016/j.resuscitation.2015.10.013</a>

Result language

angličtina

Original language name

Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33 degrees C and 36 degrees C

Original language description

Introduction: The optimal temperature during targeted temperature management (TTM) for comatose patients resuscitated from out-of-hospital cardiac arrest is unknown. It has been hypothesized that patients with long no-flow times, for example those without bystander CPR would have the most to gain from temperature management at lower temperatures. Methods: We analysed data from an international clinical trial randomizing cardiac arrest patients to targeted temperature management at 33 degrees C and 36 degrees C for an interaction between no-flow time and intervention group, with neurological function at six months after cardiac arrest as the primary outcome. A cerebral performance category (CPC) score of 1 or 2 was considered a good outcome. Results: No-flow time (min) was associated with poor neurological outcome (OR 1.13, 95% confidence interval 1.06-1.20, p < 0.001). There was no statistically significant interaction between no flow-time and intervention group (p = 0.11), which may imply that the non-superior effect of 33 degrees C was consistent for all no-flow times. Bystander CPR was not independently associated with neurological function. Conclusions: TTM at 33 degrees C compared to 36 degrees C was not associated with an increased probability of a good neurological function for patients with longer no-flow times.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Resuscitation

ISSN

0300-9572

e-ISSN

—

Volume of the periodical

99

Issue of the periodical within the volume

February

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

44-49

UT code for WoS article

000370180700017

EID of the result in the Scopus database

2-s2.0-84954338677