Visual evoked potentials in patients after methanol poisoning

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10325278" target="_blank" >RIV/00064165:_____/16:10325278 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10325278 RIV/75010330:_____/16:00011317

Result on the web

<a href="http://ijomeh.eu/Visual-Evoked-Potentials-in-Patients-after-Methanol-Poisoning,58665,0,2.html" target="_blank" >http://ijomeh.eu/Visual-Evoked-Potentials-in-Patients-after-Methanol-Poisoning,58665,0,2.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.13075/ijomeh.1896.00452" target="_blank" >10.13075/ijomeh.1896.00452</a>

Result language

angličtina

Original language name

Visual evoked potentials in patients after methanol poisoning

Original language description

Objectives: We report the results of the visual evoked potentials (VEP) examination in patients after severe poisoning by methanol. Material and Methods: The group of 47 patients (38 males and 9 females) was assembled out of persons who survived an outbreak of poisoning by the methanol adulterated alcohol beverages, which happened in the Czech Republic in 2012-2013. The visual evoked potentials examination was performed using monocular checkerboard pattern-reversal stimulation. Two criteria of abnormality were chosen: missing evoked response, and wave P1 latency > 117 ms. Non-parametric statistical methods (median, range, and the median test) were used to analyze factors influencing the VEP abnormality. Results: The visual evoked potential was abnormal in 20 patients (43%), 5 of them had normal visual acuity on the Snellen chart. The VEP abnormality did not correlate significantly with initial serum concentrations of methanol, formic acid or lactate; however, it showed statistically significant inverse relation to the initial serum pH: the subgroup with the abnormal VEP had significantly lower median pH in comparison with the subgroup with the normal VEP (7.16 vs. 7.34, p = 0.04). The abnormality was not related to chronic alcohol abuse. Conclusions: The visual evoked potentials examination appeared sensitive enough to detected even subclinical impairment of the optic system. Metabolic acidosis is likely to be the key factor related to the development of visual damage induced by methanol. The examination performed with a delay of 1-9 months after the poisoning documented the situation relatively early after the event. It is considered as a baseline for the planned long-term follow-up of the patients, which will make it possible to assess the dynamics of the observed changes, their reversibility, and the occurrence of potential late sequelae.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

—

Continuities

O - Projekt operacniho programu

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Occupational Medicine and Environmental Health

ISSN

1232-1087

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

471-478

UT code for WoS article

000372970100011

EID of the result in the Scopus database

2-s2.0-84968649854