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Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326822" target="_blank" >RIV/00064165:_____/16:10326822 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/16:00090716 RIV/00216208:11110/16:10326822

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ygyno.2016.07.008" target="_blank" >http://dx.doi.org/10.1016/j.ygyno.2016.07.008</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ygyno.2016.07.008" target="_blank" >10.1016/j.ygyno.2016.07.008</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience

  • Original language description

    Objective. The aim of our study was to describe oncological and obstetrical outcomes in patients who underwent less radical fertility-sparing surgical (FSS) procedures with omitted parametrectomy for cervical cancer. Methods. Included were women with cervical cancer stages IA2-IB2 who were under the age of 40 and desired future pregnancy. Patients underwent pelvic lymphadenectomy and sentinel lymph node biopsy. Node negative cases underwent subsequent cervical surgery and were further analyzed. Nebadjuvant chemotherapy (NAC) was administered in patients with tumors >2 cm and/or involving >2/3 of cervical stroma. Simple vaginal trachelectomy or needle conization were performed according to tumor extent and topography. The follow-up period started once free surgical margins were reached. Results. Out of 44 women enrolled, 32 women (IA2 = 7, IB1 = 23, IB2 = 2) successfully completed FSS. NAC was administered in 9 (28.1%) cases. A simple trachelectomy was performed in 11 patients and needle conization in 21 patients. During the follow-up, 6 out of 32 women became pregnant Of these, 1 miscarried and 5 successfully delivered. Disease recurred in 6 patients; 5 recurrences were central and 1 recurrence presented as an ovarian mass. Invasive cervical carcinoma, high-grade squamous intraepithelial (HSIL), and low-grade squamous intraepithelial (LSIL) lesions were detected in 4,1 and 1 patients, respectively. Three of them received NAC. All events were detected within 16 months after surgery. Conclusions. Nearly 27% of patients cannot complete FSS due to node positivity, progression during NAC, or involved margins. The total recurrence rate reached 18.8%, with the majority of invasive recurrences detected in patients after NAC followed by FSS. These patients represent cases at a higher risk of recurrence even if adequate free margins are reached by surgery. Nearly half of the cohort did not consider pregnancy in the near future because of personal reasons.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FK - Gynaecology and obstetrics

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Gynecologic Oncology

  • ISSN

    0090-8258

  • e-ISSN

  • Volume of the periodical

    142

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    4

  • Pages from-to

    401-404

  • UT code for WoS article

    000383115200005

  • EID of the result in the Scopus database

    2-s2.0-84990197041