Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326822" target="_blank" >RIV/00064165:_____/16:10326822 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00090716 RIV/00216208:11110/16:10326822
Result on the web
<a href="http://dx.doi.org/10.1016/j.ygyno.2016.07.008" target="_blank" >http://dx.doi.org/10.1016/j.ygyno.2016.07.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygyno.2016.07.008" target="_blank" >10.1016/j.ygyno.2016.07.008</a>
Alternative languages
Result language
angličtina
Original language name
Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience
Original language description
Objective. The aim of our study was to describe oncological and obstetrical outcomes in patients who underwent less radical fertility-sparing surgical (FSS) procedures with omitted parametrectomy for cervical cancer. Methods. Included were women with cervical cancer stages IA2-IB2 who were under the age of 40 and desired future pregnancy. Patients underwent pelvic lymphadenectomy and sentinel lymph node biopsy. Node negative cases underwent subsequent cervical surgery and were further analyzed. Nebadjuvant chemotherapy (NAC) was administered in patients with tumors >2 cm and/or involving >2/3 of cervical stroma. Simple vaginal trachelectomy or needle conization were performed according to tumor extent and topography. The follow-up period started once free surgical margins were reached. Results. Out of 44 women enrolled, 32 women (IA2 = 7, IB1 = 23, IB2 = 2) successfully completed FSS. NAC was administered in 9 (28.1%) cases. A simple trachelectomy was performed in 11 patients and needle conization in 21 patients. During the follow-up, 6 out of 32 women became pregnant Of these, 1 miscarried and 5 successfully delivered. Disease recurred in 6 patients; 5 recurrences were central and 1 recurrence presented as an ovarian mass. Invasive cervical carcinoma, high-grade squamous intraepithelial (HSIL), and low-grade squamous intraepithelial (LSIL) lesions were detected in 4,1 and 1 patients, respectively. Three of them received NAC. All events were detected within 16 months after surgery. Conclusions. Nearly 27% of patients cannot complete FSS due to node positivity, progression during NAC, or involved margins. The total recurrence rate reached 18.8%, with the majority of invasive recurrences detected in patients after NAC followed by FSS. These patients represent cases at a higher risk of recurrence even if adequate free margins are reached by surgery. Nearly half of the cohort did not consider pregnancy in the near future because of personal reasons.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gynecologic Oncology
ISSN
0090-8258
e-ISSN
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Volume of the periodical
142
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
401-404
UT code for WoS article
000383115200005
EID of the result in the Scopus database
2-s2.0-84990197041