Phthalates exposure indicators determined by urinary phthalate metabolites in healthy non-obese Czech adults: FANTOM study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326937" target="_blank" >RIV/00064165:_____/16:10326937 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10326937 RIV/00216208:11140/16:10326937 RIV/00669806:_____/16:10326937 RIV/75010330:_____/16:00011467

Result on the web

<a href="http://dx.doi.org/10.1080/19440049.2016.1241898" target="_blank" >http://dx.doi.org/10.1080/19440049.2016.1241898</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/19440049.2016.1241898" target="_blank" >10.1080/19440049.2016.1241898</a>

Result language

angličtina

Original language name

Phthalates exposure indicators determined by urinary phthalate metabolites in healthy non-obese Czech adults: FANTOM study

Original language description

It is assumed that human exposure to phthalates may be associated with adverse health effects. The indicators of urinary phthalate metabolite concentrations in healthy adults are limited. In our study the phthalate metabolites concentrations were detected from 24-hour urine collection in non-obese Czech adults (n=201). Each participant filled in an 80-item questionnaire (FANTOM-SQ 2013) regarding the outdoor and indoor sources of phthalates, the use of personal care products and the food intake sources. The concentrations of 15 phthalates metabolites were analyzed following enzymatic cleavage of the glucuronide using ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC -ESI-MS/MS). The indicators of chronic or acute exposure phthalate-containing materials were identified. We have shown that higher fruit consumption was positively and significantly associated with higher level of total 15 urinary phthalates biomarkers (p-value <0.001). Regular meat consumption showed negative significant association with total 15 phthalates metabolites (p-value <0.01). The use of personal care products was significantly and positively correlated with monoethyl phthalate urine concentrations (p-value <0.05). The analysis of the dietary behavior and the personal care products use in Czech non-obese population showed to be predictable tool in the level of phthalates exposure when high fruit consumption and personal care products use are linked to higher phthalate metabolites contents in the urine. However this topic deserves more research.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT14182" target="_blank" >NT14182: The role of phthalates and estrogene endocrine disruptors in the development of metabolic diseases.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment

ISSN

1944-0049

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1817-1825

UT code for WoS article

000388957300007

EID of the result in the Scopus database

2-s2.0-84992169555