Methotrexate efficacy, but not its intolerance, is associated with the dose and route of administration

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327302" target="_blank" >RIV/00064165:_____/16:10327302 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00091332 RIV/00216208:11110/16:10327302 RIV/65269705:_____/16:00065609
Result on the web
<a href="http://dx.doi.org/10.1186/s12969-016-0099-z" target="_blank" >http://dx.doi.org/10.1186/s12969-016-0099-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12969-016-0099-z" target="_blank" >10.1186/s12969-016-0099-z</a>

Result language
angličtina
Original language name
Methotrexate efficacy, but not its intolerance, is associated with the dose and route of administration
Original language description
Background: There is a lack of published evidence on the importance of methotrexate (MTX) dose and route of administration on both its efficacy and adverse events in children with Juvenile Idiopathic Arthritis (JIA). We aimed to document our clinical practice based on the treat-to-target approach in order to support the concept that better therapeutic effect achieved with an optimal dose of parenteral MTX is associated with clinically acceptable adverse effects comparable to those reported for oral treatment. Methods: Study inclusion criteria were indication of new MTX therapy for active arthritis in confirmed JIA patients younger than 18 years. Eligible patients were evaluated prospectively every 3 months for 1 year using standardized instruments for treatment response (American College of Rheumatology Pediatric (ACRPedi) response, Juvenile Arthritis Disease Activity Score (JADAS) 71, Clinically Inactive Disease (CID)) and adverse events (laboratory monitoring, Methotrexate Intolerance Severity Score (MISS)). MTX responders had to achieve at least ACRPedi 70 response. MTX intolerance was defined by MISS >=6.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
—

Project
<a href="/en/project/NT14149" target="_blank" >NT14149: Quality of life in children with juvenile idiopathic arthritis: Importance of allied health professions in the complex treatment programme</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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