Risk of micrometastases in non-sentinel pelvic lymph nodes in cervical cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327413" target="_blank" >RIV/00064165:_____/16:10327413 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00091060 RIV/00216208:11110/16:10327413

Result on the web

<a href="http://dx.doi.org/10.1016/j.ygyno.2016.07.101" target="_blank" >http://dx.doi.org/10.1016/j.ygyno.2016.07.101</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ygyno.2016.07.101" target="_blank" >10.1016/j.ygyno.2016.07.101</a>

Result language

angličtina

Original language name

Risk of micrometastases in non-sentinel pelvic lymph nodes in cervical cancer

Original language description

Objective. A high sensitivity of sentinel lymph nodes (SLN) for pelvic lymph node (LN) staging has been repeatedly shown in patients with cervical cancer. However, since only SLN are evaluated by pathologic ultrastaging, the risk of small metastases, including small macrometastases (MAC) and micrometastases (MIC), in non-SLN is unknown. This can be a critical limitation for the oncological safety of abandoning a pelvic lymphadenectomy. Methods. The patients selected for the study had cervical cancer and were at high risk for LN positivity (stage IB-IIA, biggest diameter >= 3 cm). The patients had no enlarged or suspicious LN on pre-operative imaging; SLNs were detected bilaterally and were negative on intra-operative pathologic evaluation. All SLNs and all other pelvic LNs were examined using an ultrastaging protocol and processed completely in intervals of 150 mu m. Results. In all, 17 patients were enrolled into the study. The mean number of removed pelvic LNs was 30. A total of 573 pelvic LNs were examined through ultrastaging protocol (5762 slides). Metastatic involvement was detected in SLNs of 8 patients (1 x MAC; 4x MIC; 3x ITC) and in non-SLNs in 2 patients (2x MIC), In both cases with positive pelvic non-SLNs, there were found MIC in ipsilateral SLNs. No metastasis in pelvic nonSLNs was found by pathologic ultrastaging in any of the patients with negative SLN Side-specific sensitivity was 100% for MAC and MIC. There was one case of ITC detected in non-SLN, negative ipsilateral SLN, but MIC in SLN on the other pelvic side. Conclusions. After processing all pelvic LNs by pathologic ultrastaging, there were found no false-negative cases of positive non-SLN (MAC or MIC) and negative SLN. SLN ultrastaging reached 100% sensitivity for the presence of both MAC and MIC in pelvic LNs.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

—

Project

<a href="/en/project/NV16-31643A" target="_blank" >NV16-31643A: Sentinel lymph node biopsy versus systematic pelvic lymphadenectomy in patients with early stages cervical cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gynecologic Oncology

ISSN

0090-8258

e-ISSN

—

Volume of the periodical

143

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

83-86

UT code for WoS article

000384391800014

EID of the result in the Scopus database

2-s2.0-84990250643