Efficacy of Sunitinib in Elderly Patients with Metastatic Renal Cell Carcinoma: Data from Real-World Clinical Practice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327745" target="_blank" >RIV/00064165:_____/16:10327745 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10327745 RIV/00216208:11130/16:10327745 RIV/00216208:11140/16:10327745 RIV/61989592:15110/16:33160653 and 5 more

Result on the web

<a href="http://dx.doi.org/10.1007/s40266-016-0390-1" target="_blank" >http://dx.doi.org/10.1007/s40266-016-0390-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40266-016-0390-1" target="_blank" >10.1007/s40266-016-0390-1</a>

Result language

angličtina

Original language name

Efficacy of Sunitinib in Elderly Patients with Metastatic Renal Cell Carcinoma: Data from Real-World Clinical Practice

Original language description

Background Although a significant proportion of patients with metastatic renal cell carcinoma (mRCC) are elderly, the data on the outcomes of targeted therapies in this population are limited. The aim of the present retrospective registry-based study was to analyse efficacy and toxicity of sunitinib as the first-line targeted therapy of elderly mRCC patients. Patients and Methods The national RENal information system registry of mRCC patients treated with targeted agents in the Czech Republic was used as the data source. Of the 1315 patients treated with sunitinib as first-line targeted therapy, 1016 and 299 patients were aged < 70 and aeyen70 years, respectively. Results Elderly patients had a significantly longer interval from diagnosis to the initiation of therapy. Median progression-free survival was 10.8 months (95 % confidence interval 9.8-11.8) and 8.8 months (7.2-10.4) for patients aged < 70 and aeyen70 years, respectively (p = 0.321). Median overall survival was 31.9 months (27.9-35.9) and 26.3 months (21.3-31.2), respectively (p = 0.044). Significantly more elderly patients started on a reduced dose of sunitinib or discontinued the treatment prior to progression because of adverse events. Conclusions The differences in patient profile and dose-reduction rates point to a different approach in the management of older and younger patients in daily clinical practice. The lower dose intensity of sunitinib in the elderly population may have translated into inferior survival.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NV15-34678A" target="_blank" >NV15-34678A: Prognostic and predictive molecular factors in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drugs and Aging

ISSN

1170-229X

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

9

Country of publishing house

NZ - NEW ZEALAND

Number of pages

9

Pages from-to

655-663

UT code for WoS article

000384433400005

EID of the result in the Scopus database

2-s2.0-84982273742