The role of 18F-FDG PET/CT in diagnosis and therapeutic approach in small child with MSMD

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327886" target="_blank" >RIV/00064165:_____/16:10327886 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10327886

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The role of 18F-FDG PET/CT in diagnosis and therapeutic approach in small child with MSMD

Original language description

Case report presents the role of 18F-FDG PET/CT in diagnosis and therapeutic approach in small child with Mendelian susceptibility to mycobacterial diseases (MSMD). One of defects from this group a dominant mutation c818-821delTTAA was detected in present patient. She was vaccinated on 9th postnatal day. Within the following months she suffered from disseminated BCG infection. In biopsy tissues Mycobacterium bovis was isolated and girl was treated with regiment of four antituberculotics, which induced clinical remission. New episode of illness flared up three years later, with right hip pain, cervical lymphadenopathy and 2 lumps on skull. Surprisingly, cultures of material obtained from occipital lesion yielded colonies of Mycobacterium avium (subspecies avium). Two 18F-FDG PET/CT studies were performed during the second mycobacteriosis: the initial one before initiation of antituberculotics and the second one after 6 weeks of therapy. The initial 18F-FDG PET/CT scan confirmed internal dissemination. Lesions with high 18F-FDG uptake were founds in two lesions in the skull, in the cervical lymph nodes on the left side, in the left lung, spleen and in right proximal femur. Initial therapy with four antituberculotics was adjusted according to microbiological sensitivity. According to 18F-FDG PET/CT finding a surgical removal of the frontal skull and hip lesions was performed and the limb was immobilized by plaster fixation. Follow-up 18F-FDG PET/CT scan 6 weeks after start of new therapy demonstrated apparent regression of all pathological lesions Among the advantages of 18F-FDG PET/CT is the combination of functional imaging and precise anatomic localization of biopsy sites for subsequent histological examination Conclusion: 18F-FDG PET/CT determined the extent of disseminated BCGosis, particularized the finding of bone lesions and evaluated the effect of the antituberculous treatment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nuklearmedizin

ISSN

0029-5566

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

3

Pages from-to

"N49"-"N51"

UT code for WoS article

000384036700007

EID of the result in the Scopus database

2-s2.0-84988849407