Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10328387" target="_blank" >RIV/00064165:_____/16:10328387 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/16:00302848 RIV/00216208:11110/16:10328387

Result on the web

<a href="http://dx.doi.org/10.7717/peerj.2530" target="_blank" >http://dx.doi.org/10.7717/peerj.2530</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7717/peerj.2530" target="_blank" >10.7717/peerj.2530</a>

Result language

angličtina

Original language name

Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease

Original language description

Background. Although increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson's disease (PD) and Huntington's disease (HD) are very sparse. The aim of the current study was to analyze acoustic and perceptual correlates of velopharyngeal seal closure in 37 PD and 37 HD participants in comparison to 37 healthy control speakers. Methods. Acoustical analysis was based on sustained phonation of the vowel /i/ and perceptual analysis was based on monologue. Perceptual analysis was performed by 10 raters using The Great Ormond Street Speech Assessment '98. Acoustic parameters related to changes in a 1/3-octave band centered on '1 kHz were proposed to reflect nasality lewl and behavior through utterance. Results. Perceptual analysis showed the occurrence of mild to moderate hyyernasality in 65% of PD, 89% of HD and 22% of control speakers. Based on acoustic analyses, 27% of PD 54% of HD and 19% of control speakers showed an increased occurrence of hypernasafity. In addition, 78% of HD patients demonstrated a high occurrence of intermittent hypernasality. Further results indicated relationships between the acoustic parameter representing fluctuation of nasality and perceptual assessment (r = 0.51, p <,0.001) as well as the Unified Huntington Disease Rating Scale chorea composite subscore r = 0.42, p =0.01). Conclusions. In conclusion the acoustic assessment showed that abnormal nasality was not a common feature of PD, whereas patients with HD manifested intermittent hypernasality associated with chorea.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/NV15-28038A" target="_blank" >NV15-28038A: Speech disorders and analysis of their mechanisms in Parkinson's disease and other movement disorders.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PeerJ

ISSN

2167-8359

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

September

Country of publishing house

US - UNITED STATES

Number of pages

19

Pages from-to

—

UT code for WoS article

000385572500007

EID of the result in the Scopus database

2-s2.0-84991376216