Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10329151" target="_blank" >RIV/00064165:_____/16:10329151 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10329151

Result on the web

<a href="http://dx.doi.org/10.1111/cei.12813" target="_blank" >http://dx.doi.org/10.1111/cei.12813</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cei.12813" target="_blank" >10.1111/cei.12813</a>

Result language

angličtina

Original language name

Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women

Original language description

Anti-C1q antibodies (anti-C1q) have been implicated in the pathogenesis of autoimmune diseases, including autoimmune thyroid disorders (AITD). The aim of this study was to evaluate the association between anti-C1q and thyroid function in pregnancy-associated AITD. In 96 pregnant women screened positive for AITD (thyroid dysfunction and/or antibodies against thyroperoxidase - TPOAb), anti-C1q were measured during the 9-11th gestational week and after delivery (median 16 months after delivery), and compared to the corresponding serum levels of thyroid hormones. As controls, 80 healthy pregnant women, 72 non-pregnant AITD patients and 72 blood donors were included. In the non-pregnant AITD group, two serum samples >= 6 months apart were analysed. Compared to blood donors, anti-C1q levels were substantially higher in all pregnant women analysed. In pregnancy, anti-C1q levels were higher in the TPOAb-positive women than in controls (37 versus 17.5%, P < 0.0001). Anti-C1q-positive pregnant women screened positive for AITD had higher thyroid-stimulating hormone (TSH) levels than anti-C1q-negative women (2.41 versus 1.94 mU/l, P = 0.01), and TSH correlated positively with anti-C1q (r = 0.226, P = 0.045) in the TPOAb-positive women. After delivery, serum levels of anti-C1q decreased in the positively screened TPOAb-negative women (8.8 versus 5.9 U/l, P = 0.002), but not in the TPOAb-positive ones, and they no longer correlated with TSH. Anti-C1q antibody levels increase during pregnancy in general and even more in the context of AITD, where they correlate with thyroid stimulating hormone levels.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Experimental Immunology

ISSN

0009-9104

e-ISSN

—

Volume of the periodical

186

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

10-17

UT code for WoS article

000386088500002

EID of the result in the Scopus database

2-s2.0-84991267316