Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10330797" target="_blank" >RIV/00064165:_____/16:10330797 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10330797

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.09.075" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2016.09.075</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.09.075" target="_blank" >10.1016/j.ijcard.2016.09.075</a>

Result language

angličtina

Original language name

Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement

Original language description

Although statin therapy has proven to be the cornerstone for prevention and treatment of cardiovascular disease (CVD), there are many patients for whom long-term therapy remains suboptimal. The aims of this article are to review the current complex issues associated with statin use and to explore when novel treatment approaches should be considered. Statin discontinuation as well as adherence to statin therapy remain two of the greatest challenges for lipidologists. Evidence suggests that between 40 and 75% of patients discontinue their statin therapy within one year after initiation. Furthermore, whilst the reasons for persistence with statin therapy are complex, evidence shows that low-adherence to statins negatively impacts clinical outcomes and residual CV risk remains a major concern. Non-adherence or lack of persistence with long-term statin therapy in real-lifemay be the main cause of inadequate lowdensity lipoprotein cholesterol loweringwith statins. There is a large need for the improvement of the use of statins,which have good safety profiles and are inexpensive. On the other hand, in a non-cost-constrained environment, proprotein convertase subtilisin/kexin type 9 inhibitors should arguably be used more often in those patients in whom treatment with statins remains unsatisfactory.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Volume of the periodical

225

Issue of the periodical within the volume

December

Country of publishing house

IE - IRELAND

Number of pages

13

Pages from-to

184-196

UT code for WoS article

000390472000042

EID of the result in the Scopus database

2-s2.0-84990196360