Peritoneal lavage examination as a prognostic tool in cases of gastric cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10362573" target="_blank" >RIV/00064165:_____/17:10362573 - isvavai.cz</a>

Alternative codes found

RIV/00064211:_____/17:W0000026

Result on the web

<a href="http://dx.doi.org/10.5114/aoms.2016.64044" target="_blank" >http://dx.doi.org/10.5114/aoms.2016.64044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/aoms.2016.64044" target="_blank" >10.5114/aoms.2016.64044</a>

Result language

angličtina

Original language name

Peritoneal lavage examination as a prognostic tool in cases of gastric cancer

Original language description

Introduction: Peritoneal tumor seeding is a common form of recurrence after gastric cancer surgery. The finding of free tumor cells and/or elevation of tumor markers in the peritoneal fluid could predict intraperitoneal tumor recurrence. The results of these examination can be used for indication of aggressive treatment modalities such as hyperthermic intraperitoneal chemotherapy (HIPEC). Material and methods: We have operated on 105 patients suffering from gastric cancer. The control group consisted of 12 patients without malignant disease. Peritoneal lavage fluid or ascites was collected immediately after laparotomy and examined by cytology and biochemistry (levels of carcinoembryonic antigen (CEA) and Ca 19-9). Sensitivity, specificity, stage correlation and overall survival were observed. Results: Elevation of tumor markers or the finding of free intraperitoneal tumor cells predicts recurrence. The prognosis of these patients is same as in stage IV TNM classification with median survival time less than 1 year (p = 0.713). Patients with negative cytology have median survival time 5 years contrary to them with positive cytology (p &lt; 0.001). Sensitivity of the cytology was 34% and specificity was 85%. Sensitivity of biochemistry was 53% (combination of both markers) and specificity was 100%. Conclusions: This study confirms the importance of peritoneal fluid examination for the prognosis. We cannot recommend routine use as an indicator for HIPEC due to low sensitivity, but the result of cytological examination is an independent factor for patient survival.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Medical Science

ISSN

1734-1922

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

5

Pages from-to

612-616

UT code for WoS article

000400418600015

EID of the result in the Scopus database

2-s2.0-85019542471