Mild cognitive impairment disrupts attention network connectivity in Parkinson's disease: A combined multimodal MRI and meta-analytical study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10375755" target="_blank" >RIV/00064165:_____/18:10375755 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10375755

Result on the web

<a href="https://doi.org/10.1016/j.neuropsychologia.2018.03.011" target="_blank" >https://doi.org/10.1016/j.neuropsychologia.2018.03.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuropsychologia.2018.03.011" target="_blank" >10.1016/j.neuropsychologia.2018.03.011</a>

Result language

angličtina

Original language name

Mild cognitive impairment disrupts attention network connectivity in Parkinson's disease: A combined multimodal MRI and meta-analytical study

Original language description

Mild cognitive impairment (MCI) affects approximately one-third of non-demented Parkinson&apos;s Disease (PD) patients. We aimed at investigating the neural correlates of MCI in PD combining multimodal magnetic resonance imaging (MRI) with large-scale data from the literature. We analyzed 31 PD patients and 30 matched controls. The standard neuropsychological assessment of PD-MCI covered memory, attention, executive functions, language and visuospatial abilities. Following validated criteria, 16 patients were classified as showing MCI. Whole-brain functional connectivity and structural volume changes were assessed, respectively, by means of eigenvector centrality (EC) and voxel-based morphometry. To address the involvement of specific functional brain networks, we validated our results by building a meta-analytic co-activation map (MACM) based on the previous literature and then testing its overlap with the parcellation of functional networks derived from 1000 healthy controls. The EC comparison between PD with normal cognition and controls showed a selective decline in interconnectedness in the bilateral lentiform nuclei. Differently, comparing PD with MCI and controls revealed additional changes in non-motor areas. Directly comparing PD with and without MCI, we found a reduced interconnectedness in the bilateral superior parietal lobules and precuneus. No differences in brain volume were detected comparing these patient groups. The MACM and overlap analyses showed that the observed connectivity changes were localized in the hubs of the dorsal attention network. Notably, this aligned with the predominant attention deficit observed in our sample. Overall, functional impairment in the dorsal attention network seems to be the hallmark of MCI due to PD, thus extending previous findings of brain connectivity disruption in non-motor networks.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA16-13323S" target="_blank" >GA16-13323S: MIcro and MAcro Connectomics of the Subthalamic nucleus in humans: impact of neuromodulation and dopamine depletion</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychologia

ISSN

0028-3932

e-ISSN

—

Volume of the periodical

112

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

105-115

UT code for WoS article

000430521500012

EID of the result in the Scopus database

2-s2.0-85044033982