All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10380156" target="_blank" >RIV/00064165:_____/18:10380156 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985858:_____/18:00493427 RIV/00216208:11110/18:10380156 RIV/00216208:11510/18:10380156 RIV/46747885:24210/18:00008847

  • Result on the web

    <a href="https://doi.org/10.3390/nano8080611" target="_blank" >https://doi.org/10.3390/nano8080611</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/nano8080611" target="_blank" >10.3390/nano8080611</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites

  • Original language description

    Researchers in nanocomposite processing may inhale a variety of chemical agents, including nanoparticles. This study investigated airway oxidative stress status in the exhaled breath condensate (EBC). Nineteen employees (42.4 +/- 11.4 y/o), working in nanocomposites research for 18.0 +/- 10.3 years were examined pre-shift and post-shift on a random workday, together with nineteen controls (45.5 +/- 11.7 y/o). Panels of oxidative stress biomarkers derived from lipids, nucleic acids, and proteins were analyzed in the EBC. Aerosol exposures were monitored during three major nanoparticle generation operations: smelting and welding (workshop 1) and nanocomposite machining (workshop 2) using a suite of real-time and integrated instruments. Mass concentrations during these operations were 0.120, 1.840, and 0.804 mg/m(3), respectively. Median particle number concentrations were 4.8 x 10(4), 1.3 x 10(5), and 5.4 x 10(5) particles/cm(3), respectively. Nanoparticles accounted for 95, 40, and 61%, respectively, with prevailing Fe and Mn. All markers of nucleic acid and protein oxidation, malondialdehyde, and aldehydes C-6-C-13 were elevated, already in the pre-shift samples relative to controls in both workshops. Significant post-shift elevations were documented in lipid oxidation markers. Significant associations were found between working in nanocomposite synthesis and EBC biomarkers. More research is needed to understand the contribution of nanoparticles from nanocomposite processing in inducing oxidative stress, relative to other co-exposures generated during welding, smelting, and secondary oxidation processes, in these workshops.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30304 - Public and environmental health

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nanomaterials

  • ISSN

    2079-4991

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    19

  • Pages from-to

  • UT code for WoS article

    000443257500050

  • EID of the result in the Scopus database

    2-s2.0-85051636359