Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10382781" target="_blank" >RIV/00064165:_____/18:10382781 - isvavai.cz</a>

Alternative codes found

RIV/67985858:_____/18:00493430 RIV/00216208:11110/18:10382781 RIV/00216208:11510/18:10382781 RIV/46747885:24210/18:00008848

Result on the web

<a href="https://doi.org/10.3390/nano8090731" target="_blank" >https://doi.org/10.3390/nano8090731</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nano8090731" target="_blank" >10.3390/nano8090731</a>

Result language

angličtina

Original language name

Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers

Original language description

Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m(3) to 1.840 mg/m(3) during nanocomposite machining processes; median particle number concentration ranged from 4.8 x 10(4) to 5.4 x 10(5) particles /cm(3). The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (p &lt; 0.05). Post-shift EBC samples were higher for TNF (p &lt; 0.001), LTB4 (p &lt; 0.001), and LTE4 (p &lt; 0.01) compared with controls. Nanocomposites production was associated with LTB4 (p &lt; 0.001), LTE4 (p &lt; 0.05), and TNF (p &lt; 0.001), in addition to pre shift LTD4 and LXB4 (both p &lt; 0.05). Spirometry documented minor, but significant, post shift lung impairment. TNF and LTB4 were the most robust markers of biological effects. Proper ventilation and respiratory protection are required during nanocomposites processing.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanomaterials

ISSN

2079-4991

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

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UT code for WoS article

000448659200099

EID of the result in the Scopus database

2-s2.0-85053809227