Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10383161" target="_blank" >RIV/00064165:_____/18:10383161 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10383161 RIV/68407700:21460/18:00327284 RIV/00216208:11120/18:43917373 RIV/00023884:_____/18:00007887
Result on the web
<a href="http://dx.doi.org/10.1038/s41598-018-34880-z" target="_blank" >http://dx.doi.org/10.1038/s41598-018-34880-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-018-34880-z" target="_blank" >10.1038/s41598-018-34880-z</a>
Alternative languages
Result language
angličtina
Original language name
Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition
Original language description
Clinical benefits of pallidal deep brain stimulation (GPi DBS) in dystonia increase relatively slowly suggesting slow plastic processes in the motor network. Twenty-two patients with dystonia of various distribution and etiology treated by chronic GPi DBS and 22 healthy subjects were examined for short-latency intracortical inhibition of the motor cortex elicited by paired transcranial magnetic stimulation. The relationships between grey matter volume and intracortical inhibition considering the long-term clinical outcome and states of the GPi DBS were analysed. The acute effects of GPi DBS were associated with a shortening of the motor response whereas the grey matter of chronically treated patients with a better clinical outcome showed hypertrophy of the supplementary motor area and cerebellar vermis. In addition, the volume of the cerebellar hemispheres of patients correlated with the improvement of intracortical inhibition which was generally less effective in patients than in controls regardless of the DBS states. Importantly, good responders to GPi DBS showed a similar level of short-latency intracortical inhibition in the motor cortex as healthy controls whereas non-responders were unable to increase it. All these results support the multilevel impact of effective DBS on the motor networks in dystonia and suggest potential biomarkers of responsiveness to this treatment
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
November
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
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UT code for WoS article
000450768100012
EID of the result in the Scopus database
2-s2.0-85056971664