Imaging Parkinsonian Pathology in Substantia Nigra with MRI
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10392375" target="_blank" >RIV/00064165:_____/18:10392375 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10392375
Result on the web
<a href="https://doi.org/10.1007/s40134-018-0272-x" target="_blank" >https://doi.org/10.1007/s40134-018-0272-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40134-018-0272-x" target="_blank" >10.1007/s40134-018-0272-x</a>
Alternative languages
Result language
angličtina
Original language name
Imaging Parkinsonian Pathology in Substantia Nigra with MRI
Original language description
Purpose of Review: The substantia nigra pars compacta (SNc) and its projection to the striatum undergo profound degeneration in Parkinson's disease (PD). Literature on imaging PD-related changes in the nigrostriatal system using iron-sensitive and diffusion-sensitive MRI contrasts has been contentious, with both negative and positive results reported in each contrast. These incompatible findings may be due to the inaccurate placement of regions of interest for the SNc. Recent Findings: Histologically, SNc is characterized by the presence of melanized dopamine neurons, whereas the substantia nigra pars reticulata is characterized by high iron content. Despite this histology, previous studies have frequently relied upon iron-sensitive MRI contrast when segmenting the SNc. This is also problematic since recent work found iron-sensitive and neuromelanin-sensitive contrasts are largely non-overlapping in substantia nigra. Since neuromelanin-sensitive MRI contrast colocalizes with the melanized dopamine neurons of the SNc upon radiologic-histologic correlation, the use of neuromelanin-sensitive MRI will allow for accurate localization of SNc and better capture parkinsonian pathobiology than iron-sensitive MRI. Summary: This article outlines iron-sensitive and diffusion-sensitive MRI contrasts, and provides an overview of neuromelanin-sensitive MRI techniques. The application of these techniques to image parkinsonian pathobiology in substantia nigra is then reviewed, with a focus on neuromelanin-sensitive imaging methods for the accurate and reproducible study of PD-related changes in SNc. These advances may help resolve current controversies surrounding MRI investigations of substantia nigra in PD and related disorders.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Radiology Reports [online]
ISSN
2167-4825
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85056459811