Prevalence of restless legs syndrome in functional movement disorders: A case-control study from the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10393036" target="_blank" >RIV/00064165:_____/19:10393036 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10393036

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=H3r.1W3Yna" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=H3r.1W3Yna</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/bmjopen-2018-024236" target="_blank" >10.1136/bmjopen-2018-024236</a>

Result language

angličtina

Original language name

Prevalence of restless legs syndrome in functional movement disorders: A case-control study from the Czech Republic

Original language description

Objectives The prevalence of restless legs syndrome (RLS) in functional movement disorders (FMD) is not known. Patients with FMD often present with multiple motor and sensory symptoms. Some of these symptoms might be due to comorbid RLS. Therefore, our objective was to evaluate possible association between FMD and RLS. Design Case-control study. Setting Movement Disorders Center, 1st Faculty of Medicine and General University Hospital in Prague, Czech Republic. Participants 96 consecutive patients with clinically established FMD (80 females, mean age (SD) 45.0 (13) years), and 76 matched controls. Primary and secondary outcome measures The primary outcome measure was prevalence of RLS based on updated International RLS Study Group criteria. Secondary outcome measures included prevalence of periodic limb movements (PLM) using actigraphy; pain, motor and sensory symptoms in lower limbs; organic comorbidities and medication affecting RLS. Results RLS criteria were fulfilled in 43.8% of patients (95% CI 34 to 54) and in 7.9% of controls (95% CI 3 to 17, p&lt;0.00001). Both RLS and PLM indices (PLMi) &gt;=22.5/hour were found in 21.2% of patients with FMD and 2.6% of controls. Patients with FMD with RLS had a higher mean PLMi (p&lt;0.001) and a higher proportion of PLMi &gt;=22.5/hour (p&lt;0.01) than RLS-negative patients. Patients with RLS had higher prevalence of pain and sensory symptoms in lower limbs, no difference was found in medication and prevalence of organic comorbidities in patients with FMD with and without RLS. Conclusions We found an increased prevalence of RLS in patients with FMD. Clinical diagnosis of RLS was supported by actigraphic measurement of clinically relevant PLM in a significant proportion of patients with FMD. Although functional motor and sensory symptoms may mimic RLS, RLS may be unrecognised in patients with FMD. This finding may have clinical implications in management of FMD, and it raises the possibility of common pathophysiological mechanisms of FMD and RLS/PLM

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV16-29651A" target="_blank" >NV16-29651A: Diagnostic neurophysiological and laboratory markers and pathophysiological mechanisms of functional movement disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMJ Open [online]

ISSN

2044-6055

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

e024236

UT code for WoS article

000471116800167

EID of the result in the Scopus database

2-s2.0-85060400100