All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

First-line therapy for T cell lymphomas: a retrospective population-based analysis of 906 T cell lymphoma patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395706" target="_blank" >RIV/00064165:_____/19:10395706 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00112767 RIV/00216208:11110/19:10395706 RIV/00216208:11120/19:43918234 RIV/00216208:11130/19:10395706 and 6 more

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Y.NqkvUs_T" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Y.NqkvUs_T</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00277-019-03694-y" target="_blank" >10.1007/s00277-019-03694-y</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    First-line therapy for T cell lymphomas: a retrospective population-based analysis of 906 T cell lymphoma patients

  • Original language description

    Peripheral T cell lymphomas (PTLs) have a globally poor prognosis. The CHOP regimen shows insufficient efficacy; first-line consolidation with autologous stem cell transplantation (auto-SCT) is a promising strategy but has never been confirmed by randomized data. We analyzed retrospectively 906 patients diagnosed with PTL between 1999 and 2015. Chemotherapy was given to 862 patients, and 412 of them were &lt;60years. In this subset, we compared induction with CHOP (n=113) vs. CHOEP (n=68) and tested auto-SCT (n=79) vs. no SCT (n=73) in the intent-to-treat analysis. The median age of the whole cohort at diagnosis was 60years (range; 18-91); the median follow-up was 4.3years (range; 0.1-17.8). A shorter overall survival (OS) was associated with the male gender, age &gt;= 60years, stage III/IV, performance status &gt;= 2, bulky tumor &gt;= 10cm, and elevated LDH. CHOEP induction showed a better 5-year PFS (25.0% vs. 32.9%; p.001), and 5-year OS (65.6% vs. 47.6%; p.008) than CHOP. Auto-SCT compared to no SCT brought a 5-year OS of 49.2% vs. 59.5% (p.187). Auto-SCT did not influence the OS in low-risk or low-intermediate risk PTLs. The high-intermediate and high-risk IPIs displayed a worse 5-year OS in auto-SCT arm (17.7% vs.46.2%; p.049); however, 73.9% of the patients never received planned auto-SCT. Our population-based analysis showed the superiority of CHOEP over CHOP in first-line treatment. We confirm the 5-year OS of around 50% in PTLs undergoing auto-SCT. However, the intended auto-SCT could not be given in 73.9% of the high-risk PTLs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

    <a href="/en/project/NV16-31092A" target="_blank" >NV16-31092A: Population of Elderly Patients with Non-Hodgkin´s Lymphomas – the Analysis of Factors Affecting the Management and Outcome</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Annals of Hematology

  • ISSN

    0939-5555

  • e-ISSN

  • Volume of the periodical

    98

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    12

  • Pages from-to

    1961-1972

  • UT code for WoS article

    000475694100018

  • EID of the result in the Scopus database

    2-s2.0-85065474059