All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Plasma osteopontin levels in patients with dilated and hypertrophic cardiomyopathy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395855" target="_blank" >RIV/00064165:_____/19:10395855 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10395855

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v6QXyLmewd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v6QXyLmewd</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00059-017-4645-3" target="_blank" >10.1007/s00059-017-4645-3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plasma osteopontin levels in patients with dilated and hypertrophic cardiomyopathy

  • Original language description

    Background: Osteopontin (OPN) is an extracellular matrix glycoprotein that plays a role in a variety of cellular activities associated with inflammatory and fibrotic responses. Increased OPN levels in myocardium and plasma have been demonstrated in patients with dilated cardiomyopathy (DCM). However, nothing is known about OPN levels in patients with hypertrophic cardiomyopathy (HCM). Therefore, the aim of our study was to compare plasma OPN levels in patients with these two most common cardiomyopathies. Patients and methods: We examined plasma OPN as well as creatinine, C-reactive protein (CRP), brain-type natriuretic peptide (BNP), and troponin I levels in 64 patients with DCM, 43 patients with HCM, and 75 control subjects. Transthoracic echocardiography was also performed on all cardiomyopathy patients. Results: Plasma OPN levels were significantly elevated in patients with DCM compared with HCM patients (95 +- 43 vs. 57 +- 21 ng/ml; p &lt; 0.001) and control subjects (54 +- 19 ng/ml; p &lt; 0.001); however, there was no difference between HCM patients and control subjects. New York Heart Association (NYHA) class III or IV disease was more frequently present in DCM patients than in HCM subjects (44 % vs. 2 %, p &lt; 0.0001). In multivariate analysis, BNP and CRP levels together with NYHA class were found to be significant predictors of plasma OPN levels in DCM patients (p = 0.002, p = 0.029, and p &lt; 0.001 for BNP, CRP, and NYHA, respectively). Conclusion: Plasma OPN levels were associated with overall heart failure severity rather than with specific cardiomyopathy subtype in patients suffering from DCM or HCM, respectively.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Herz

  • ISSN

    0340-9937

  • e-ISSN

  • Volume of the periodical

    44

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    7

  • Pages from-to

    347-353

  • UT code for WoS article

    000471606200010

  • EID of the result in the Scopus database

    2-s2.0-85034265053