Plasma osteopontin levels in patients with dilated and hypertrophic cardiomyopathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395855" target="_blank" >RIV/00064165:_____/19:10395855 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10395855
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v6QXyLmewd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v6QXyLmewd</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00059-017-4645-3" target="_blank" >10.1007/s00059-017-4645-3</a>
Alternative languages
Result language
angličtina
Original language name
Plasma osteopontin levels in patients with dilated and hypertrophic cardiomyopathy
Original language description
Background: Osteopontin (OPN) is an extracellular matrix glycoprotein that plays a role in a variety of cellular activities associated with inflammatory and fibrotic responses. Increased OPN levels in myocardium and plasma have been demonstrated in patients with dilated cardiomyopathy (DCM). However, nothing is known about OPN levels in patients with hypertrophic cardiomyopathy (HCM). Therefore, the aim of our study was to compare plasma OPN levels in patients with these two most common cardiomyopathies. Patients and methods: We examined plasma OPN as well as creatinine, C-reactive protein (CRP), brain-type natriuretic peptide (BNP), and troponin I levels in 64 patients with DCM, 43 patients with HCM, and 75 control subjects. Transthoracic echocardiography was also performed on all cardiomyopathy patients. Results: Plasma OPN levels were significantly elevated in patients with DCM compared with HCM patients (95 +- 43 vs. 57 +- 21 ng/ml; p < 0.001) and control subjects (54 +- 19 ng/ml; p < 0.001); however, there was no difference between HCM patients and control subjects. New York Heart Association (NYHA) class III or IV disease was more frequently present in DCM patients than in HCM subjects (44 % vs. 2 %, p < 0.0001). In multivariate analysis, BNP and CRP levels together with NYHA class were found to be significant predictors of plasma OPN levels in DCM patients (p = 0.002, p = 0.029, and p < 0.001 for BNP, CRP, and NYHA, respectively). Conclusion: Plasma OPN levels were associated with overall heart failure severity rather than with specific cardiomyopathy subtype in patients suffering from DCM or HCM, respectively.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Herz
ISSN
0340-9937
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
347-353
UT code for WoS article
000471606200010
EID of the result in the Scopus database
2-s2.0-85034265053