Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395906" target="_blank" >RIV/00064165:_____/19:10395906 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10395906 RIV/00064190:_____/19:N0000010 RIV/00216208:11120/19:43918500
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EfFYVe7QbE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EfFYVe7QbE</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinbiochem.2019.08.005" target="_blank" >10.1016/j.clinbiochem.2019.08.005</a>
Alternative languages
Result language
angličtina
Original language name
Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview
Original language description
Neuropathological diagnostic criteria of neurodegenerative disorders are based on the presence of specific inclusions in a specific area of brain tissue that correlate with clinical manifestations. Concomitant neurodegenerative disorders correspond to a combination of two (or more) different fully developed diseases in the same patient. Concomitant neurodegenerative pathology represents the presence of definite neurodegeneration and deposits of pathological proteins specific for another disease, which is not, however, fully developed. Very frequent overlaps include Alzheimer's disease and alpha-synuclein inclusions. Nevertheless, careful neuropathological investigations reveal an increasing frequency of different co-pathologies in examined brains. In Alzheimer's disease, proteinTDP-43 may co-aggregate, but it is not clear whether this is atypical isolated Alzheimer's disease or overlap of Alzheimer's disease with early frontotemporal lobar degeneration. Comorbidities of Alzheimer's disease and tauopathies are relatively rare. A combination of vascular pathology with primary neurodegeneration (mostly Alzheimer's disease or dementia with Lewy bodies) is historically called mixed dementia. Overlap of different neuropathologically confirmed neurodegenerations could lead to atypical and unusual clinical presentations and may be responsible for faster disease progression. Several CSF biomarkers have been evaluated for their utility in diagnostic processes in different neurodegenerative dementias; however, evidence regarding their role in neurodegenerative overlaps is still limited.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Biochemistry
ISSN
0009-9120
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
November
Country of publishing house
CA - CANADA
Number of pages
6
Pages from-to
26-31
UT code for WoS article
000492745500003
EID of the result in the Scopus database
2-s2.0-85070405739