Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10396107" target="_blank" >RIV/00064165:_____/19:10396107 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00107343 RIV/00159816:_____/19:00071172

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XxpLSCDDSG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XxpLSCDDSG</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2019/6802349" target="_blank" >10.1155/2019/6802349</a>

Result language

angličtina

Original language name

Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus

Original language description

Recent studies have suggested a bidirectional relationship between chronic periodontitis (CP) and diabetes mellitus (DM). Immunoregulatory factors such as cytokines play an important role in etiopathogenesis of both diseases. The aim of this study was to analyze variability in interleukin-1 (IL-1) gene cluster and IL-1 plasma levels in patients with CP, DM, and a combination of both diseases. A total of 1016 individuals participating in this case-control study225 healthy controls, 264 patients with CP, 132 with type 1 diabetes (T1DM), and 395 patients with type 2 diabetes (T2DM)were genotyped using methods based on polymerase chain reaction for IL-1 gene polymorphisms (IL-1A (-889C/T, rs1800587), IL-1B (+3953C/T, rs1143634), and IL-1RN (gene for IL-1 receptor antagonist, IL-1RA, 86bp tandem repeats in intron 2)). Levels of IL-1 were measured by Luminex methods in subgroups of controls, CP, T1DM+CP, and T2DM+CP subjects. Although no significant associations were found in the genotype and allele frequencies of IL-1A (-889C/T), significant differences in the allele frequencies of IL-1B (+3953C/T) were observed between controls and CP patients (P&lt;0.05). In T1DM patients, IL-1RNS short allele and IL-1RN 12 genotype were significantly less frequent than those in controls (P&lt;0.01). In haplotype analysis, TTL haplotype decreased the risk of CP development (P&lt;0.01), whereas CCS and CTL haplotypes (P&lt;0.01 and P&lt;0.05) were associated with T1DM. Although IL-1 levels were measured significantly higher in mononuclear cells after stimulation by mitogens, HSP70, or selected periodontal bacteria than in unstimulated cells, IL-1 genotypes did not correlate with circulating IL-1 levels. In the Czech population, significant associations between the IL-1B polymorphism with CP and the IL-1RN variant with T1DM were found. Haplotype analysis suggests that variability in IL-1 gene cluster may be one of the factors in the CP and T1DM pathogenesis, although single variants of these polymorphisms are not substantial for protein production.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

<a href="/en/project/GB14-37368G" target="_blank" >GB14-37368G: Centre of orofacial development and regeneration</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Dentistry

ISSN

1687-8728

e-ISSN

—

Volume of the periodical

2019

Issue of the periodical within the volume

January

Country of publishing house

EG - EGYPT

Number of pages

10

Pages from-to

6802349

UT code for WoS article

000457007900001

EID of the result in the Scopus database

2-s2.0-85060815678