Olfactory dysfunction in a cohort of Czech patients with idiopathic REM sleep behaviour disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10396686" target="_blank" >RIV/00064165:_____/19:10396686 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10396686

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=56VbfjP6ck" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=56VbfjP6ck</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2019415" target="_blank" >10.14735/amcsnn2019415</a>

Result language

angličtina

Original language name

Olfactory dysfunction in a cohort of Czech patients with idiopathic REM sleep behaviour disorder

Original language description

Aim: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a sleep abnormality heralded by the absence of physiological atonia in REM sleep and dream enactment behaviour. Idiopathic RBD (iRBD), dia g nosed when no primary RBD cause can be identified, is a marker of prodromal synucleinopathy with a high conversion rate to overt neurodegenerative disorders from the synucleinopathy group. The aim of this cross-sectional study was to investigate olfactory function in iRBD patients and its relation to other symptoms. Patients and methods: This study included 54 iRBD patients with a median age of 67 (IQR 63-72) years; the 37 control subjects, matched by gender and age, had a median age of 67 (57.5-70.0) years. All subjects underwent a complex examination, which included olfactory testing using the University of Pennsylvania Smell Identifi cation Test (UPSIT). Results: In total, 62.9% of iRBD patients had either total loss of olfactory function or severe hyposmia. In contrast, only 8.1% of controls showed such a degree of olfactory dysfunction. Furthermore, we found that the percentage of REM sleep without atonia on polysomnography negatively correlates with the UPSIT score (P &lt; 0.01). Conclusion: This study demonstrated a signifi cantly lower olfactory function in the iRBD group compared to controls.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

50101 - Psychology (including human - machine relations)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Volume of the periodical

82

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

415-419

UT code for WoS article

000500970200011

EID of the result in the Scopus database

2-s2.0-85071115337