Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10397517" target="_blank" >RIV/00064165:_____/19:10397517 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10397517
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RCX.RNDNMM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RCX.RNDNMM</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14767058.2018.1432039" target="_blank" >10.1080/14767058.2018.1432039</a>
Alternative languages
Result language
angličtina
Original language name
Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia
Original language description
Aim: Phenobarbital (PB) pharmacokinetics (PK) in asphyxiated newborns show large variability, not only explained by hypothermia (HT). We evaluated potential relevant covariates of PK of PB in newborns treated with or without HT for hypoxic-ischemic encephalopathy (HIE). Methods: Clearance (CL), distribution volume (Vd) and elimination half-life (t(1/2)) were calculated using one-compartment analysis. Covariates were clinical characteristics (weight, gestational age, hepatic, renal, and circulatory status), comedication and HIE severity [time to reach normal aEEG pattern (T(norm)aEEG), dichotomous, within 24 h] and asphyxia severity [severe aspyhxia = pH <= 7.1 + Apgar score <= 5 (5 min), dichotomous]. Student's t-test, two-way ANOVA, correlation and Pearson's chi-square test were used. Results: Forty newborns were included [14 non-HT; 26 HT with T(norm)aEEG <24 h in 14/26 (group(1-HT)) and T(norm)aEEG >= 24 h in 12/26 (group(2-HT))]. Severe asphyxia was present in 26/40 [5/14 non-HT, 11/14 and 10/12 in both HT groups]. PB-CL, Vd and t(1/2) were similar between the non-HT and HT group. However, within the HT group, PB-CL was significantly different between group(1-HT) and group(2-HT) (p = .043). ANOVA showed that HT (p = .034) and severity of asphyxia (p = .038) reduced PB-CL (-50%). Conclusion: The interaction of severity of asphyxia and HT is associated with a clinical relevant reduced PB-CL, suggesting the potential relevance of disease characteristics beyond HT itself.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Maternal-Fetal & Neonatal Medicine
ISSN
1476-7058
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
2302-2309
UT code for WoS article
000463528600005
EID of the result in the Scopus database
2-s2.0-85041559803