Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10398449" target="_blank" >RIV/00064165:_____/19:10398449 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10398449 RIV/00216208:11130/19:10398449 RIV/00064203:_____/19:10398449
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=82r-iDIM0l" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=82r-iDIM0l</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-019-0451-7" target="_blank" >10.1038/s41375-019-0451-7</a>
Alternative languages
Result language
angličtina
Original language name
Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions
Original language description
We have identified a minor BCR within the human MLL gene that is recurrently associated in acute leukemia patients with MLL-USP2 fusion alleles as well as MLL fusion partnerships with USP8,AF4, and AF9. However, with 17 cases out of ~2500 analyzed patients the incidence is less than 1% while still ranking fourteenth of our updated fusion gene list (see Table 1 of reference1).The discovery of a second, minor BCR extends ourknowledge of the MLL-recombinome and MLL-r oncogenesis. Moreover, thesefindings will enable many labs tomake changes in their diagnostic set-up for MLL-MRD diagnostics to ensure the best medical treatment for a group of patients that is still very hard to cure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
—
Volume of the periodical
33
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
2306-2310
UT code for WoS article
000484399300014
EID of the result in the Scopus database
2-s2.0-85063349147