Three-layer collagen-based vascular graft designed for low-flow peripheral vascular reconstructions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10398594" target="_blank" >RIV/00064165:_____/19:10398594 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21220/19:00330610 RIV/00216208:11110/19:10398594
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QwU-tGF2qo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QwU-tGF2qo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.32725/jab.2019.002" target="_blank" >10.32725/jab.2019.002</a>

Result language
angličtina
Original language name
Three-layer collagen-based vascular graft designed for low-flow peripheral vascular reconstructions
Original language description
Introduction: The aim of this study was to develop a prototype of an artificial blood vessel which has similar mechanical properties to a human saphenous vein graft and to experimentally verify the function of the prosthesis via ovine carotid bypass implantation. Material and methods: The prototype of an artificial graft prosthesis for low flow was developed and manufactured from a collagenous matrix and reinforcing polyester mesh. We compared the results of both the pressurisation and the mechanical stress evaluation tests of VSM with four types of hybrid vascular graft. The most similar graft (type II) was chosen for the first ovine model implantation. Results: Dominant behavior e.g. mechanical response of VSM graft in plots of circumferential and axial stress during loading is observed in circumferential direction. Average results of used VSM showed area of ideal mechanical response and the properties of artificial blood vessels were fitted into this area. Developed graft remained patent after 161 days of follow up in ovine model. Conclusions: The mechanical properties of the graft were designed and adjusted to be similar to the behaviour of human saphenous veins. This approach showed promising results and enhanced the final performance of the prosthesis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery

Project
<a href="/en/project/NV15-27941A" target="_blank" >NV15-27941A: The use of nonatigen fish collagen in construction of implants and as drug carriers.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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