Deregulation of selected microRNAs in sinonasal squamous cell Carcinoma: Searching for Potential Prognostic Biomarkers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399496" target="_blank" >RIV/00064165:_____/19:10399496 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10399496 RIV/00216208:11150/19:10399496 RIV/61989592:15110/19:73595699 RIV/00179906:_____/19:10399496

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=C0HdJdP-dk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=C0HdJdP-dk</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Deregulation of selected microRNAs in sinonasal squamous cell Carcinoma: Searching for Potential Prognostic Biomarkers

Original language description

Sinonasal carcinomas are head and neck tumors arising from nasal cavity and paranasal sinuses characterized by unfavorable outcome, difficult treatment, diagnosis and prognosis. MicroRNAs are key molecules in the regulation of development and progression of cancer and their expression profiles could be used as prognostic biomarkers, to predict patients&apos; survival and response to treatment. In this study, we used quantitative real time PCR with TaqMan(R) Advanced miRNA Assays to investigate relative expression values of selected microRNAs in a unique set of formalin-fixed paraffin-embedded tissue samples obtained from 46 patients with sinonasal squamous cell carcinoma. Our results showed statistically significant upregulation of three mature microRNAs: miR-9-5p (fold change: 6.80), miR-9-3p (fold change: 3.07) and let-7d (fold change: 3.93) sinonasal carcinoma patients. Kaplan-Meier survival analysis and Logrank test identified connection between higher expression of miR-9-5p and longer survival of the patients (P = 0.0264). Lower expression of let-7d was detected in the patients with impaired survival and higher expression of miR-137 was linked to shorter survival of the patients. We also identified several correlations between expression of studied microRNAs and recorded clinicopathological data. Higher expression of miR-137, lower expression of let-7d correlated with local recurrence (P = 0.045 and P = 0.025), lower expression of miR-9-5p and higher expression of miR-155-5p correlated with regional recurrence (P = 0.045 and P = 0.036). Higher expression of miR-9-3p correlated with occupational risk (P = 0.031), presence of vascular invasion (P = 0.013) and perineural invasion (P = 0.031). Higher expression of miR-155-5p was present in the samples originating from maxillary sinus (P = 0.011), cN1-3 classified tumors (P = 0.009) and G2-3 classified tumors (P = 0.017). In conclusion, our study supports the hypothesis of future prospect to use miRNA expression as prognostic biomarkers of squamous cell sinonasal carcinoma. Especially, miR-9-5p and miR-9-3p seem to be important members of sinonasal cancer pathogenesis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

<a href="/en/project/EF16_013%2F0001674" target="_blank" >EF16_013/0001674: BBMRI-CZ: Biobank network - a versatile platform for the research of the etiopathogenesis of diseases</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

142-151

UT code for WoS article

000500271800004

EID of the result in the Scopus database

2-s2.0-85073656014