Eye hazard classification according to UN GHS/EU CLP and the severity of eye symptoms caused by accidental exposures to detergents and cleaning products
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10400018" target="_blank" >RIV/00064165:_____/19:10400018 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10400018
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MD2TXsP5T5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MD2TXsP5T5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yrtph.2019.04.004" target="_blank" >10.1016/j.yrtph.2019.04.004</a>
Alternative languages
Result language
angličtina
Original language name
Eye hazard classification according to UN GHS/EU CLP and the severity of eye symptoms caused by accidental exposures to detergents and cleaning products
Original language description
The use of lower cut-off values/concentration limits for the calculation of mixture classification in UN GHS/EU CLP versus the previous regulatory scheme (EU Dangerous Preparations Directive, DPD), has resulted in an increased number of classifications in the highest eye hazard category. Herein, a semi-quantitative categorisation of severity of eye effects, following accidental human exposures to detergents, was compared to the classification category of the products. Three schemes were evaluated: EU DPD; EU CLP (based on all available data and information, including weight of evidence); and EU CLP (based entirely on the calculation method). As reported by four EU Poison Centres, the vast majority of exposures had caused minor or no symptoms. Classification was a poor predictor of effects in man subjected to accidental exposure. Note however that this is also because effects are not only driven by the intrinsic hazard (as reflected in the classification), but also by the exposure conditions and mitigation (i.e. rinsing). EU CLP classification using all available data and information was more predictive of medically relevant symptoms than the EU CLP calculation method. The latter led to a poorer differentiation between irritating products versus products potentially causing serious eye damage.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Regulatory Toxicology and Pharmacology
ISSN
0273-2300
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
July
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
69-76
UT code for WoS article
000476683800008
EID of the result in the Scopus database
2-s2.0-85064178819