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Search for biomarkers of Alzheimer's disease: Recent insights, current challenges and future prospects

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10400049" target="_blank" >RIV/00064165:_____/19:10400049 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10400049 RIV/60461373:22340/19:43918845

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wroXlE8BNw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wroXlE8BNw</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinbiochem.2019.04.002" target="_blank" >10.1016/j.clinbiochem.2019.04.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Search for biomarkers of Alzheimer's disease: Recent insights, current challenges and future prospects

  • Original language description

    Due to the trend of prolonged lifespan leading to higher incidence of age-related diseases, the demand for reliable biomarkers of dementia rises. In this review, we present novel biomarkers of high potential, especially those found in blood, urine or saliva, which could lead to a more comfortable patient experience and better time- and cost-effectivity, compared to the currently used diagnostic methods. We focus on biomarkers that might allow for the detection of Alzheimer&apos;s disease before its clinical manifestations. Such biomarkers might be helpful for better understanding the etiology of the disease and identifying its risk factors. Moreover, it could be a base for developing new treatment or at least help to prolong the presymptomatic stage in patients suffering from Alzheimer&apos;s disease. As potential candidates, we present, for instance, neurofilament light in both cerebrospinal fluid and blood plasma or amyloid beta in plasma. Above all, we provide an overview of different approaches to the diagnostics, analyzing patient&apos;s biofluids as a whole using molecular spectroscopy. Infrared and Raman spectroscopy and especially chiroptical methods provide information not only on the chemical composition, but also on molecular structure. Therefore, these techniques are promising for the diagnostics of Alzheimer&apos;s disease, as the accumulation of amyloid beta in abnormal conformation is one of the hallmarks of this disease.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    <a href="/en/project/GA17-05292S" target="_blank" >GA17-05292S: Novel blood-based biomarkers for early diagnosis, prognosis and progress of Alzheimer's disease</a><br>

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Biochemistry

  • ISSN

    0009-9120

  • e-ISSN

  • Volume of the periodical

    72

  • Issue of the periodical within the volume

    October

  • Country of publishing house

    CA - CANADA

  • Number of pages

    13

  • Pages from-to

    39-51

  • UT code for WoS article

    000486413800007

  • EID of the result in the Scopus database

    2-s2.0-85064078438