Blood Pressure Profile, Catecholamine Phenotype, and Target Organ Damage in Pheochromocytoma/Paraganglioma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10401100" target="_blank" >RIV/00064165:_____/19:10401100 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10401100 RIV/00216208:11120/19:43918122 RIV/00064173:_____/19:N0000140

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1gtnIPhqxB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1gtnIPhqxB</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2018-02644" target="_blank" >10.1210/jc.2018-02644</a>

Result language

angličtina

Original language name

Blood Pressure Profile, Catecholamine Phenotype, and Target Organ Damage in Pheochromocytoma/Paraganglioma

Original language description

CONTEXT: Impaired diurnal blood pressure (BP) variability is related to higher cardiovascular risk. OBJECTIVE: To assess diurnal variability of BP and its relation to target organ damage (TOD) and catecholamine phenotype in a consecutive sample of pheochromocytoma/paraganglioma (PPGL). DESIGN: We included 179 patients with PPGL (96 females). All patients underwent 24h ambulatory blood pressure monitoring (SpaceLabs 90207) to determine dipping status. Differences in plasma metanephrine or urine adrenaline were used to distinguish catecholamine biochemical phenotype. To evaluate TOD, renal functions, presence of left ventricle hypertrophy (LVH) and, in the subgroup (N=111) carotid-femoral PWV, were assessed. Structural equation modeling was used to find the relationship among nocturnal dipping, catecholamine phenotype and TOD parameters. RESULTS: According to the nocturnal dipping, patients were divided into the three groups -dippers (28 %), non-dippers (40 %) and reverse dippers (32 %). Reverse dippers were older (P&lt;0.05), with a higher proportion of noradrenergic phenotype (P&lt;0.05), a higher prevalence of diabetes mellitus (P&lt;0.05), sustained arterial hypertension (P&lt;0.01) and its duration (P&lt;0.05) as opposed to the other groups. All parameters of TOD were more pronounced only in reverse dippers, in comparison with non-dippers and dippers. The presence of noradrenergic biochemical phenotype (=absence of adrenaline production) was associated with reverse dipping and TOD (LVH and PWV). CONCLUSIONS: Only patients with reverse dipping had more significant TOD compared to other groups. The noradrenergic biochemical phenotype plays an important role not only in impaired diurnal BP variability, but also, independently from dipping status, in more pronounced TOD of heart and vessels.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV16-30345A" target="_blank" >NV16-30345A: Pheochromocytoma as a model of chronic activation of the stress axis in the pathogenesis of metabolic disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Journal of Clinical Endocrinology &amp; Metabolism

ISSN

0021-972X

e-ISSN

—

Volume of the periodical

104

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

5170-5180

UT code for WoS article

000497979600030

EID of the result in the Scopus database

2-s2.0-85071019278